Tag Archives: depression

More Data on the Neuroactive Steroid Zuranolone for Postpartum Depression

While we have heard a lot about brexanolone, marketed by Sage Therapeutics as Zulresso, for the treatment of postpartum depression, an oral version of this novel antidepressant – SAGE 217 or zuranolone – has been finishing up its Phase 3 trials. Like brexanolone, SAGE-217 is a neuroactive steroid, an analogue of allopregnanolone which is a… Read More »

Perimenopausal Depression in Women with More Variable Levels of Estradiol and Lower Progesterone Levels

Women are at increased risk for depressive symptoms during the menopause transition.  It has long been suspected that falling estrogen levels play a role in triggering the onset of depression; however, if all women experience declining levels of estrogen and progesterone during this transition, why is it that only some women suffer from depression in… Read More »

What causes vascular depression

Cerebral white matter lesions and subjective cognitive dysfunction. For example, inflammation participates in vascular remodeling, accelerates vascular damage what can contribute to perfusion deficits. Either lesion volume or severity ratings according to vascular rating scales can be inferred. However, the disorder is causes described as vascular depression in the literature. If data on moderator or… Read More »